Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF ifo r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2977501	0.1733113	0.1005066
Weighted median	23	-0.2254381	0.0583596	0.0001120
Inverse variance weighted	23	-0.2875270	0.0661796	0.0000139
Simple mode	23	-0.2556708	0.1000197	0.0180054
Weighted mode	23	-0.2198446	0.0649885	0.0026788

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	62.59450	21	5.1e-06
Inverse variance weighted	62.60674	22	9.1e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006278	0.009796	0.9495102

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0035228	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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