Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF ifo l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3110699	0.1744072	0.0889513
Weighted median	23	-0.2227817	0.0595195	0.0001818
Inverse variance weighted	23	-0.2827187	0.0666411	0.0000221
Simple mode	23	-0.2535466	0.0920760	0.0115901
Weighted mode	23	-0.2265889	0.0658348	0.0023270

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	63.38823	21	3.9e-06
Inverse variance weighted	63.48237	22	6.7e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017409	0.0098579	0.8615136

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0034956	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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