Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF fmi

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2804305	0.1730211	0.1199829
Weighted median	23	-0.1437199	0.0624314	0.0213326
Inverse variance weighted	23	-0.2207229	0.0662837	0.0008686
Simple mode	23	-0.1881699	0.1036152	0.0830170
Weighted mode	23	-0.1698157	0.0692435	0.0225878

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	62.38389	21	5.5e-06
Inverse variance weighted	62.80142	22	8.5e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036664	0.0097795	0.7114918

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0028612	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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