Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF fma

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2877400	0.1573388	0.0816698
Weighted median	23	-0.1595640	0.0587708	0.0066271
Inverse variance weighted	23	-0.2255213	0.0603388	0.0001858
Simple mode	23	-0.1618758	0.0955117	0.1042186
Weighted mode	23	-0.1716988	0.0614744	0.0106023

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.58765	21	0.0002185
Inverse variance weighted	52.04104	22	0.0003086

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038206	0.0088931	0.6718555

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.002577	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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