Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF cst r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2604464	0.1378297	0.0726936
Weighted median	23	-0.1678251	0.0574914	0.0035101
Inverse variance weighted	23	-0.1736943	0.0532097	0.0010972
Simple mode	23	-0.1336813	0.0952243	0.1743207
Weighted mode	23	-0.1648390	0.0623402	0.0148173

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.58713	21	0.0083446
Inverse variance weighted	40.46856	22	0.0095261

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053271	0.0077904	0.5015798

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018199	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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