Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF cst l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2884619	0.1423547	0.0556165
Weighted median	23	-0.2006716	0.0589638	0.0006658
Inverse variance weighted	23	-0.1730390	0.0553501	0.0017704
Simple mode	23	-0.2131467	0.1053926	0.0554580
Weighted mode	23	-0.1934737	0.0645789	0.0066571

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.22991	21	0.0039364
Inverse variance weighted	43.79026	22	0.0037669

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070876	0.0080462	0.3883598

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019161	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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