Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF cgh r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1551931	0.1178578	0.2021012
Weighted median	23	-0.0774927	0.0617372	0.2094050
Inverse variance weighted	23	-0.1561079	0.0450010	0.0005224
Simple mode	23	-0.0446002	0.1137124	0.6986702
Weighted mode	23	-0.0560747	0.0804038	0.4928493

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.94489	21	0.1153309
Inverse variance weighted	28.94499	22	0.1464381

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-5.62e-05	0.0066615	0.9933521

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013567	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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