Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF cgh l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1710538	0.1042159	0.1156196
Weighted median	23	-0.0979558	0.0602020	0.1037118
Inverse variance weighted	23	-0.1230230	0.0400291	0.0021168
Simple mode	23	-0.0590510	0.1058797	0.5826682
Weighted mode	23	-0.1127277	0.0669936	0.1065806

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.63194	21	0.3639120
Inverse variance weighted	22.90212	22	0.4072743

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029493	0.0058904	0.6217915

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009919	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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