Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF cgc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2684069	0.1492313	0.0864734
Weighted median	23	-0.1409732	0.0638669	0.0272933
Inverse variance weighted	23	-0.1588509	0.0578368	0.0060229
Simple mode	23	-0.1829055	0.1115938	0.1154306
Weighted mode	23	-0.1325848	0.0881651	0.1468475

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.40795	21	0.0011275
Inverse variance weighted	47.81369	22	0.0011481

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067274	0.0084349	0.434049

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001945	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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