Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF cgc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1841594	0.1407841	0.2049783
Weighted median	23	-0.0881613	0.0686344	0.1989649
Inverse variance weighted	23	-0.1231412	0.0540379	0.0226793
Simple mode	23	-0.1603548	0.1251481	0.2134226
Weighted mode	23	-0.0903503	0.0995855	0.3740988

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.30172	21	0.0051443
Inverse variance weighted	41.73778	22	0.0067239

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037469	0.0079574	0.6425921

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001563	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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