Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF atr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2672511	0.1399134	0.0698708
Weighted median	23	-0.1996945	0.0614305	0.0011511
Inverse variance weighted	23	-0.2006077	0.0537617	0.0001904
Simple mode	23	-0.1867158	0.1016693	0.0798339
Weighted mode	23	-0.1747894	0.0714665	0.0229178

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.79318	21	0.0059467
Inverse variance weighted	41.31335	22	0.0075613

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040923	0.0079082	0.6102348

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0020437	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8