Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF atr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2660209	0.1356189	0.0632095
Weighted median	23	-0.1675864	0.0621641	0.0070204
Inverse variance weighted	23	-0.2073652	0.0520539	0.0000679
Simple mode	23	-0.2305692	0.1117426	0.0510704
Weighted mode	23	-0.1675313	0.0780362	0.0430865

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.32725	21	0.0117962
Inverse variance weighted	38.73019	22	0.0151499

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036018	0.0076654	0.6432892

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0020197	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8