Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF ar r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3345243	0.1583909	0.0468371
Weighted median	23	-0.2137091	0.0586686	0.0002698
Inverse variance weighted	23	-0.2360139	0.0611311	0.0001130
Simple mode	23	-0.2365287	0.0936172	0.0192176
Weighted mode	23	-0.2170872	0.0611450	0.0017935

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	52.28081	21	0.0001742
Inverse variance weighted	53.41740	22	0.0001986

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060491	0.0089526	0.506617

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0027142	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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