Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF ar l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3051785	0.1634546	0.0759178
Weighted median	23	-0.1930547	0.0605607	0.0014337
Inverse variance weighted	23	-0.2319227	0.0627617	0.0002196
Simple mode	23	-0.2087073	0.0998853	0.0484437
Weighted mode	23	-0.2046362	0.0656062	0.0049961

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	55.67634	21	5.63e-05
Inverse variance weighted	56.30486	22	7.73e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044983	0.0092388	0.631377

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.002764	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8