Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA unc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0811434	0.1287121	0.5352170
Weighted median	23	-0.1243351	0.0566647	0.0282191
Inverse variance weighted	23	-0.1603151	0.0496649	0.0012469
Simple mode	23	-0.1032408	0.0950327	0.2890751
Weighted mode	23	-0.0816663	0.0618061	0.1999693

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.52202	21	0.0318373
Inverse variance weighted	35.25612	22	0.0364224

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048615	0.007275	0.5112518

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015741	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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