Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA unc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1543285	0.1184718	0.2067959
Weighted median	23	-0.0947699	0.0580533	0.1025818
Inverse variance weighted	23	-0.1410434	0.0452512	0.0018277
Simple mode	23	-0.1141867	0.0900197	0.2178909
Weighted mode	23	-0.1013960	0.0611917	0.1117091

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.24752	21	0.1081847
Inverse variance weighted	29.26819	22	0.1373619

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008158	0.0066962	0.9041953

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012783	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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