Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA str r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0966047	0.1345277	0.4806078
Weighted median	23	-0.0825766	0.0579998	0.1545224
Inverse variance weighted	23	-0.1402503	0.0515178	0.0064817
Simple mode	23	-0.1271635	0.1070624	0.2475972
Weighted mode	23	-0.0766498	0.0659648	0.2576946

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.71303	21	0.0139229
Inverse variance weighted	37.93614	22	0.0186264

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00268	0.0076037	0.7280005

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015366	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8