Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA str l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2015760	0.1503883	0.1944470
Weighted median	23	-0.1480793	0.0598084	0.0132902
Inverse variance weighted	23	-0.1685435	0.0574998	0.0033765
Simple mode	23	-0.1306267	0.0944721	0.1806317
Weighted mode	23	-0.1388450	0.0691801	0.0571911

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.13074	21	0.0009018
Inverse variance weighted	47.25854	22	0.0013579

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020284	0.0085002	0.813709

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019907	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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