Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA slf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1233693	0.1749201	0.4883804
Weighted median	23	-0.1210513	0.0636560	0.0572172
Inverse variance weighted	23	-0.1754330	0.0669545	0.0087883
Simple mode	23	-0.1793196	0.1156628	0.1353209
Weighted mode	23	-0.1140127	0.0739157	0.1372223

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	63.76243	21	3.4e-06
Inverse variance weighted	64.07991	22	5.5e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003197	0.0098868	0.7496216

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0025465	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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