Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA slf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2390906	0.1697419	0.1736013
Weighted median	23	-0.1231995	0.0612850	0.0444025
Inverse variance weighted	23	-0.2063042	0.0648785	0.0014735
Simple mode	23	-0.0993368	0.0965487	0.3147171
Weighted mode	23	-0.1241818	0.0608957	0.0536156

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	60.04156	21	1.26e-05
Inverse variance weighted	60.16746	22	2.11e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020132	0.0095941	0.835813

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0026599	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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