Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA ptr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3159020	0.1336965	0.0278621
Weighted median	23	-0.1816493	0.0567801	0.0013782
Inverse variance weighted	23	-0.1750735	0.0526162	0.0008767
Simple mode	23	-0.1360835	0.1023509	0.1972800
Weighted mode	23	-0.1623830	0.0593054	0.0120050

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.24926	21	0.0157580
Inverse variance weighted	39.57209	22	0.0121249

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086476	0.0075568	0.2653535

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018023	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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