Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA ptr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.4239117	0.1271112	0.0031422
Weighted median	23	-0.2054955	0.0613317	0.0008065
Inverse variance weighted	23	-0.1818441	0.0532515	0.0006383
Simple mode	23	-0.1876250	0.1142880	0.1148745
Weighted mode	23	-0.2086622	0.0683459	0.0058302

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.67143	21	0.0392822
Inverse variance weighted	40.53465	22	0.0093567

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0148644	0.0071846	0.0510855

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018791	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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