Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA ml r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0343047	0.1103873	0.7590417
Weighted median	23	-0.0399523	0.0571636	0.4846071
Inverse variance weighted	23	-0.0292531	0.0421514	0.4876807
Simple mode	23	0.0070792	0.0930918	0.9400702
Weighted mode	23	-0.0223480	0.0606662	0.7161134

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.39173	21	0.2305966
Inverse variance weighted	25.39472	22	0.2785736

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003102	0.0062392	0.9608188

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007864	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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