Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA ml l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1062607	0.1196795	0.3846633
Weighted median	23	-0.0045451	0.0599140	0.9395298
Inverse variance weighted	23	-0.0706367	0.0484215	0.1446234
Simple mode	23	-0.2743393	0.1240759	0.0377294
Weighted mode	23	-0.0014788	0.0604264	0.9806956

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.84691	21	0.0951077
Inverse variance weighted	33.51184	22	0.0550277

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0108623	0.0067644	0.1232507

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011137	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8