Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA mcp

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0120765	0.1069506	0.9111689
Weighted median	23	-0.0331411	0.0602313	0.5821616
Inverse variance weighted	23	-0.0540216	0.0410128	0.1877755
Simple mode	23	-0.0624798	0.1010428	0.5426942
Weighted mode	23	-0.0653317	0.0972341	0.5086423

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.83595	21	0.3010747
Inverse variance weighted	24.04201	22	0.3450310

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025756	0.006045	0.6743874

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007859	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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