Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA ilf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3136094	0.1443486	0.0414056
Weighted median	23	-0.1790505	0.0584184	0.0021769
Inverse variance weighted	23	-0.2573556	0.0553501	0.0000033
Simple mode	23	-0.1988817	0.0875328	0.0332076
Weighted mode	23	-0.1949275	0.0633796	0.0055321

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.42276	21	0.0027752
Inverse variance weighted	43.79340	22	0.0037635

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034543	0.0081589	0.6763244

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0026303	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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