Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA ilf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2393578	0.1706117	0.1752474
Weighted median	23	-0.1501027	0.0622443	0.0158867
Inverse variance weighted	23	-0.2374060	0.0651433	0.0002681
Simple mode	23	-0.1149239	0.0989881	0.2580903
Weighted mode	23	-0.1336813	0.0612755	0.0401033

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	60.66000	21	1.01e-05
Inverse variance weighted	60.66045	22	1.78e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001199	0.0096433	0.990201

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0029469	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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