Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA ifo r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2792358	0.1566631	0.0891499
Weighted median	23	-0.1371334	0.0609410	0.0244321
Inverse variance weighted	23	-0.2389280	0.0599286	0.0000669
Simple mode	23	-0.1032677	0.0939923	0.2837850
Weighted mode	23	-0.1242805	0.0600548	0.0504493

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.14670	21	0.0002521
Inverse variance weighted	51.33699	22	0.0003857

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024751	0.0088549	0.7825808

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0026787	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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