Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA ifo l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3096205	0.1675633	0.0787693
Weighted median	23	-0.1207625	0.0665090	0.0694114
Inverse variance weighted	23	-0.2311077	0.0643727	0.0003305
Simple mode	23	-0.1283348	0.1110298	0.2601379
Weighted mode	23	-0.1234636	0.0685682	0.0854936

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	58.51221	21	2.14e-05
Inverse variance weighted	59.23420	22	2.90e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048211	0.009471	0.6160326

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0028455	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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