Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA fmi

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3101131	0.1639348	0.0724052
Weighted median	23	-0.1667816	0.0652431	0.0105788
Inverse variance weighted	23	-0.2275239	0.0630391	0.0003071
Simple mode	23	-0.1095486	0.1164734	0.3571513
Weighted mode	23	-0.1580974	0.0811849	0.0643654

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	56.00725	21	5.03e-05
Inverse variance weighted	56.80618	22	6.55e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050714	0.0092659	0.5899285

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0027397	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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