Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA fma

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0678613	0.1363460	0.6238572
Weighted median	23	-0.0395839	0.0596613	0.5070255
Inverse variance weighted	23	-0.1579557	0.0526945	0.0027214
Simple mode	23	-0.0808818	0.0990495	0.4229236
Weighted mode	23	-0.0340394	0.0634426	0.5969712

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.73810	21	0.0105464
Inverse variance weighted	39.68872	22	0.0117530

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055322	0.0077064	0.4807498

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016935	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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