Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA cst r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1433575	0.1003877	0.1679847
Weighted median	23	-0.1171248	0.0553993	0.0344987
Inverse variance weighted	23	-0.1368188	0.0392326	0.0004878
Simple mode	23	-0.1263736	0.1005094	0.2218178
Weighted mode	23	-0.0731594	0.0699251	0.3068039

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.08762	21	0.6434530
Inverse variance weighted	18.09263	22	0.7004827

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004015	0.0056741	0.9442568

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009167	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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