Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA cst l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1330363	0.1165696	0.2666092
Weighted median	23	-0.1483997	0.0542439	0.0062231
Inverse variance weighted	23	-0.1815007	0.0447251	0.0000495
Simple mode	23	-0.1431318	0.0905036	0.1280340
Weighted mode	23	-0.1205921	0.0563324	0.0436311

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.31643	21	0.1314030
Inverse variance weighted	28.59152	22	0.1568966

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029759	0.0065887	0.6561323

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015148	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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