Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA cgh r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0309159	0.1037893	0.7687279
Weighted median	23	-0.0740421	0.0581961	0.2032717
Inverse variance weighted	23	-0.0987404	0.0401025	0.0138087
Simple mode	23	0.0793941	0.1094969	0.4760445
Weighted mode	23	-0.0660304	0.0664180	0.3309526

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.44754	21	0.3741255
Inverse variance weighted	22.98630	22	0.4025033

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041648	0.0058663	0.4855477

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008885	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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