Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA cgh l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2127942	0.1003874	0.0461114
Weighted median	23	-0.0852700	0.0544729	0.1174975
Inverse variance weighted	23	-0.0733333	0.0392327	0.0615968
Simple mode	23	-0.0180033	0.0937311	0.8494462
Weighted mode	23	-0.1093684	0.0637562	0.1003214

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.39545	21	0.9857456
Inverse variance weighted	11.67331	22	0.9637635

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085636	0.005674	0.1461323

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004596	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8