Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA cgc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2085852	0.1580162	0.2010359
Weighted median	23	-0.0799757	0.0659657	0.2253653
Inverse variance weighted	23	-0.0871003	0.0613289	0.1555447
Simple mode	23	0.0258265	0.1198246	0.8313350
Weighted mode	23	-0.0274974	0.0951574	0.7753117

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	52.03461	21	0.0001888
Inverse variance weighted	53.76321	22	0.0001776

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0074599	0.0089314	0.4129851

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017781	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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