Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA cgc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0363618	0.1229032	0.7702447
Weighted median	23	-0.0842546	0.0643781	0.1906204
Inverse variance weighted	23	-0.0527613	0.0469516	0.2611238
Simple mode	23	-0.1532936	0.1194057	0.2125672
Weighted mode	23	-0.1312789	0.0916696	0.1661744

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.47738	21	0.0660718
Inverse variance weighted	31.50888	22	0.0861631

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001007	0.0069467	0.8861225

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010096	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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