Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA atr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3122549	0.1379775	0.0343500
Weighted median	23	-0.1556784	0.0615905	0.0114832
Inverse variance weighted	23	-0.1706125	0.0542211	0.0016518
Simple mode	23	-0.0846805	0.0903004	0.3585473
Weighted mode	23	-0.1450881	0.0702624	0.0509108

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.67362	21	0.0081463
Inverse variance weighted	42.02343	22	0.0062102

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086976	0.0077988	0.2773408

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001846	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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