Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA atr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3311919	0.1276165	0.0168922
Weighted median	23	-0.2007341	0.0631740	0.0014856
Inverse variance weighted	23	-0.1721685	0.0508092	0.0007027
Simple mode	23	-0.1725913	0.1025770	0.1066020
Weighted mode	23	-0.2099443	0.0804612	0.0160134

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.93927	21	0.0367853
Inverse variance weighted	36.90118	22	0.0242532

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0097649	0.0072132	0.1902022

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017015	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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