Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA ar r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1583076	0.1356071	0.2561339
Weighted median	23	-0.1312255	0.0565843	0.0203888
Inverse variance weighted	23	-0.1913432	0.0518641	0.0002249
Simple mode	23	-0.1931222	0.0955027	0.0554849
Weighted mode	23	-0.1244549	0.0577175	0.0422587

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.32062	21	0.0118174
Inverse variance weighted	38.44844	22	0.0163086

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020285	0.0076647	0.7938514

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018853	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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