## Warning: package 'knitr' was built under R version 4.1.3

Two sample MR report

Telomere_length against IDP dMRI ProbtrackX FA ar l

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.2633889 0.1514705 0.0966966
Weighted median 23 -0.1469822 0.0590742 0.0128429
Inverse variance weighted 23 -0.1859305 0.0582583 0.0014154
Simple mode 23 -0.0920878 0.0940831 0.3383242
Weighted mode 23 -0.1552669 0.0613576 0.0190509

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 47.81213 21 0.0007293
Inverse variance weighted 48.51485 22 0.0009274

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0047563 0.0085614 0.5843837

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0021498 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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