Two sample MR report

Telomere_length against IDP T2 FLAIR BIANCA WMH volume

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0772333	0.1413562	0.5905678
Weighted median	23	0.1010929	0.0560412	0.0712465
Inverse variance weighted	23	0.1089810	0.0540385	0.0437236
Simple mode	23	0.1559371	0.0930623	0.1079689
Weighted mode	23	0.0365352	0.0620753	0.5621496

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.64502	21	0.0034880
Inverse variance weighted	42.76591	22	0.0050422

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019492	0.0079887	0.8096067

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001535	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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