Two sample MR report

Telomere_length against IDP T1 SIENAX white unnormalised volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1534628	0.1457951	0.3044897
Weighted median	23	0.0213676	0.0580609	0.7128580
Inverse variance weighted	23	0.0380238	0.0566482	0.5020754
Simple mode	23	0.1156518	0.1084436	0.2977755
Weighted mode	23	0.0147318	0.0704846	0.8363658

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.98011	21	0.0009449
Inverse variance weighted	48.63555	22	0.0008937

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0070889	0.0082408	0.3993822

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015037	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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