Two sample MR report

Telomere_length against IDP T1 SIENAX white normalised volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1497034	0.1472853	0.3209984
Weighted median	23	0.0275241	0.0578773	0.6343883
Inverse variance weighted	23	0.0368040	0.0571661	0.5196994
Simple mode	23	0.1157672	0.1141599	0.3215685
Weighted mode	23	0.0192890	0.0745856	0.7983363

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.94532	21	0.0006995
Inverse variance weighted	49.52873	22	0.0006788

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0069329	0.008325	0.4143374

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015288	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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