Two sample MR report

Telomere_length against IDP T1 SIENAX peripheral grey unnormalised volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1448516	0.1429899	0.3225810
Weighted median	23	-0.0431385	0.0642876	0.5022052
Inverse variance weighted	23	-0.0279739	0.0556203	0.6150034
Simple mode	23	-0.0305715	0.1395457	0.8286085
Weighted mode	23	-0.0973805	0.0835646	0.2563648

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.19052	21	0.001635
Inverse variance weighted	46.88752	22	0.001518

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0071773	0.0080823	0.3845844

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001437	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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