Two sample MR report

Telomere_length against IDP T1 SIENAX peripheral grey normalised volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1458239	0.1485047	0.3373040
Weighted median	23	-0.0597733	0.0632954	0.3449885
Inverse variance weighted	23	-0.0324093	0.0576329	0.5738842
Simple mode	23	-0.0565751	0.1499665	0.7096013
Weighted mode	23	-0.1042892	0.0882921	0.2501415

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.74477	21	0.0005439
Inverse variance weighted	50.34274	22	0.0005270

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069647	0.008394	0.416032

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015473	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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