Two sample MR report

Telomere_length against IDP T1 SIENAX grey unnormalised volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1191292	0.1294725	0.3679635
Weighted median	23	-0.1227880	0.0605687	0.0426366
Inverse variance weighted	23	-0.0431740	0.0499183	0.3870970
Simple mode	23	-0.1632146	0.1235488	0.2000601
Weighted mode	23	-0.1515945	0.0704073	0.0425351

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.04949	21	0.0166152
Inverse variance weighted	37.76616	22	0.0194598

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046643	0.0073182	0.5307831

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011833	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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