Two sample MR report

Telomere_length against IDP T1 SIENAX grey normalised volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1275334	0.1355892	0.3576111
Weighted median	23	-0.1316824	0.0606329	0.0298710
Inverse variance weighted	23	-0.0519791	0.0522282	0.3196241
Simple mode	23	-0.1906045	0.1383998	0.1823021
Weighted mode	23	-0.1703658	0.0780251	0.0399519

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.63372	21	0.0062216
Inverse variance weighted	41.34287	22	0.0075000

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046397	0.007664	0.5514077

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013091	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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