Two sample MR report

Telomere_length against IDP T1 SIENAX brain-unnormalised volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0309077	0.1469975	0.8354912
Weighted median	23	-0.0205806	0.0620636	0.7401879
Inverse variance weighted	23	-0.0005718	0.0562076	0.9918827
Simple mode	23	0.0729745	0.1177749	0.5418791
Weighted mode	23	-0.0194226	0.0946811	0.8393508

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.75982	21	0.0007413
Inverse variance weighted	47.88293	22	0.0011243

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019331	0.0083088	0.8182787

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014508	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8