Two sample MR report

Telomere_length against IDP T1 SIENAX brain-normalised volume

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0175378	0.1498929	0.9079700
Weighted median	23	-0.0622599	0.0618842	0.3143812
Inverse variance weighted	23	-0.0059650	0.0572806	0.9170613
Simple mode	23	0.0734354	0.1247154	0.5619771
Weighted mode	23	-0.0922576	0.0862721	0.2964924

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.66025	21	0.0004067
Inverse variance weighted	49.72887	22	0.0006380

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014433	0.0084725	0.8663661

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015074	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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